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Understanding Pharmacokinetics (PK) In A Better Way: Northeast Lab

by Kashif Khan
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Understanding Pharmacokinetics

Northeast BioLab is a full service analytical bioanalytical lab offering small and large molecule bioanalysis for clinical, preclinical, and drug discovery studies. Our team has an excellent track record of advancing Pharmacokinetics (PK), Bioavailability and Bioequivalence (BA/BE), Toxicokinetics (TK), Immunogenicity (ADA), Biomarker Testing and Custom Assays. We are GLP/GCLP compliant, FDA audited and DEA & CT State Schedule II-IV approved facility.

Northeast BioLab offers over 15 years of expertise in providing preclinical, clinical, and drug discovery studies with bioanalytical services. Our faculty has an excellent track record of advancing pharmacokinetics (PK), bioavailability and bioequivalence (BA/BE), toxicokinetics (TK), immunogenicity testing and assay development.  As the premier bioanalytical lab in the Northeast, our expanded capabilities make us a rapid deployment service provider for small and large scale projects. We have a staff of highly qualified bioanalytical experts with over 15 years experience in providing sensitive analytical services for nearly all applications.

Northeast lab is a bioanalytical lab with 15+ years experience in providing small and large molecule bioanalysis for clinical, preclinical, and drug discovery studies. Our team has an excellent track record of advancing Pharmacokinetics (PK), Bioavailability and Bioequivalence (BA/BE), Toxicokinetics (TK), Immunogenicity (ADA), Biomarker Testing, and Custom Assays. We offer Method Development and Validation using LC-MS/MS, ELISA, MSD ECL,, Luminex Multiplex , Western Blot , and qPCR , among other technologies. 

Pharmacokinetic definition:  Pharmacokinetics (PK) is the analysis and description of a substance’s disposition in the body, encompassing development of mathematical descriptions of all dispositional processes in the body. Closely related fields in the biochemical pharmacology discipline include clinical pharmacokinetics, pharmacodynamics and pharmacology. Clinical pharmacokinetics is the clinical application of basic PK principles, involving the design and modification of dosing regimens in line with therapeutic drug monitoring. Pharmacodynamics defines the relationship between plasma and tissue drug and/or metabolite concentrations, time, and therapeutic response. 

Pharmacokinetics (PK) refers to the study of how a drug is processed by the body and how it is eliminated. It includes absorption, distribution, metabolism and elimination but not all molecules are treated the same. For example, some substances remain in the blood long after they have been administered to some people, while others are removed quickly through excretion.

A pharmacokinetic deals with how the body processes and excretes drugs. The absorption, distribution and elimination of drugs are measured by pharmacokinetics to determine the effectiveness of dosage and duration. Pharmacokinetics is a branch of biopharmaceutics that deals with how your body metabolizes drugs. It includes not only drug disposition but also certain diseases such as malnutrition, metabolism disorders, liver diseases and age-related changes in drug clearance.  Pharmacokinetics is the study of the absorption, distribution and elimination process of a drug in the body. Pharmacokinetics deals with how the drug is absorbed by the blood stream, how it gets into cells, what happens to it once inside the cell and how it is processed after that.

Pharmacokinetics (PK) is the analysis and description of the disposition of a drug in the body and includes development of the mathematical description of all dispositional processes in the body and ADME – absorption, distribution, metabolism, and elimination. Related fields in the biochemical pharmacology discipline include clinical pharmacokinetics, pharmacodymamics, pharmaceutics, toxicokinetics and drug metabolism. Clinical pharmacokinetics is the clinical application of basic PK principles, involving design and modification of dosing regimens in line with therapeutic drug monitoring.”

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