So, you’ve heard the buzz. Maybe your doctor mentioned it, or a friend dropped 20 pounds and swore by it. Either way, Wegovy—the once-weekly injectable for weight loss—has landed on your radar.

It does. And quite effectively, to boot. But as with any strong drug, there are a few strings attached—side effects, in this instance. Some are expected. Others? Not so much. And being prepared for what to expect can make the difference between struggling through and giving up too early.

Let’s outline the common and rare Wegovy side effects, what to do about them, and when to call up a provider.

First, What Is Wegovy?

Wegovy (semaglutide) is a GLP-1 receptor agonist. That’s fancy medical speak for a hormone mimic that helps regulate appetite and glucose levels. It slows down how fast your stomach empties and tells your brain, “We’re full”—leading to reduced hunger, fewer cravings, and, for many people, significant weight loss.

But GLP-1 receptors don’t just live in your gut—they’re also in your brain, pancreas, and elsewhere. Which means while Wegovy targets your appetite, it can also influence other systems.

Common Wegovy Side Effects (a.k.a. the Ones Most People Experience)

Let’s start with the usual suspects. These are not dangerous, but they can be… inconvenient.

1. Nausea

The #1 side effect. Most users feel some degree of nausea, especially during the first few weeks or after a dosage increase. It’s your body adjusting to slowed digestion.

Pro tip: Eat smaller meals. Avoid high-fat foods. Ginger tea isn’t just for grandmas—it works.

2. Diarrhea or Constipation

GLP-1 slows down your GI tract. For some, that leads to sluggish digestion (hello, constipation). For others, it disrupts gut rhythm in the opposite direction.

Hydration and fiber are your best allies here. And yes, sometimes both side effects alternate. Because why not?

3. Fatigue

Your body is adjusting to a new metabolic rhythm and a different eating pattern. If you feel sluggish at first, you’re not alone. It usually gets better as your body adapts.

4. Headaches

Often tied to dehydration or electrolyte imbalance—especially if you’re eating less or losing weight rapidly.

Fix: Up your water intake and make sure you’re getting enough salt, potassium, and magnesium.

5. Burping and Gas

Yes, burping. Some people report more belching than usual. This can be linked to slower stomach emptying or minor acid reflux.

It’s not dangerous—just mildly awkward.

Less Common, But Worth Watching For

These side effects are rarer, but still documented. Some may go away on their own; others require more attention.

1. Injection Site Reactions

Redness, swelling, or itching at the injection spot isn’t uncommon, especially if you’re new to injections. Rotating sites (abdomen, thigh, upper arm) helps reduce irritation.

2. Dizziness

Usually mild and often tied to lower calorie intake or mild dehydration. But if it persists or worsens, speak up.

3. Gallbladder Issues

Weight loss, especially rapid weight loss, increases the risk of gallstones or gallbladder inflammation. Signs include sharp pain in the upper right abdomen, fever, or yellowing of the skin/eyes.

This is rare—but not unheard of.

Rare and Serious Side Effects (a.k.a. Red Flags)

Now, the serious stuff. These are uncommon, but you should be aware and alert.

1. Pancreatitis

Though rare, inflammation of the pancreas can occur. Symptoms include severe stomach pain (especially radiating to the back), nausea, and vomiting.

Don’t wait this one out—seek medical help immediately.

2. Allergic Reactions

Very rare, but serious. Signs include swelling of the face or throat, difficulty breathing, or a severe rash. Call 911. No exceptions.

3. Kidney Problems

Dehydration from nausea or vomiting can stress the kidneys. If you notice less frequent urination, swelling in your legs, or changes in how you feel overall—get evaluated.

Who Should Avoid Wegovy Entirely?

Wegovy isn’t for everyone. You shouldn’t use it if you have:

• A personal or family history of medullary thyroid cancer
  
• Multiple endocrine neoplasia syndrome type 2 (MEN2)
  
• Severe gastrointestinal disease
  
• A known allergy to semaglutide
  

Your provider will screen for these—but it’s good to know upfront.

Managing Side Effects Without Ditching the Med

The good news? Most Wegovy side effects get better over time.

The dose is increased slowly—on purpose—to help your body adjust. And small lifestyle tweaks go a long way:

• Eat slowly and mindfully
  
• Avoid greasy or rich foods
  
• Stay hydrated like it’s your full-time job
  
• Keep your provider in the loop, especially during the first couple of months
  

If you need help navigating these side effects—or deciding whether to stick with the medication—services like Amazon Pharmacy make it easier than ever to access medical guidance and prescription refills without leaving your home.

In Conclusion: Worth It? For Many—Yes

Wegovy isn’t magic. But for many people, it’s the most effective weight loss tool they’ve tried—backed by clinical data, real-world success stories, and meaningful health improvements.

The side effects? Manageable, in most cases. Temporary, for many. And worth tolerating for the benefits it can unlock.

Just keep your eyes open, your hydration game strong, and your provider on speed dial if things feel off.

Because your journey deserves support—side effects and all.